| 產(chǎn)品編號(hào) | bs-2449R |
| 英文名稱 | Rabbit Anti-CD137 antibody |
| 中文名稱 | 腫瘤壞死因子受體超家族成員9抗體 |
| 別 名 | Tumor necrosis factor receptor superfamily member 9; TNFRSF9; 4-1BB; 4 1BB; 4 1BB ligand receptor; Homolog of mouse 4 1BB; Receptor protein 4 1BB; T cell antigen 4 1BB homolog; T cell antigen ILA; CDw137; CD 137; CD137 antigen; Induced by lymphocyte activation; ILA; Interleukin activated receptor homolog of mouse Ly63; Ly63; MGC2172; MGC114552; OTTHUMP00000044294; TNR9_HUMAN. |
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Specific References (3) | bs-2449R has been referenced in 3 publications.
[IF=8.38] Daquinag, A. C., et al. "Depletion of white adipocyte progenitors induces beige adipocyte differentiation and suppresses obesity development." Cell Death & Differentiation (2014). Mouse.
[IF=3.79] Claycombe, Kate J., et al. "Decreased beige adipocyte number and mitochondrial respiration coincide with increased histone methyl transferase (9Ga) and reduced FGF21 gene expression in Sprague Dawley rats fed prenatal low protein and postnatal high fat diets." The Journal of Nutritional Biochemistry (2016). FCM ; Rat.
[IF=3.743] Lei W et al. Phthalides,?senkyunolide?A and?ligustilide, show?immunomodulatory?effect?in?improvingatherosclerosis, through?inhibiting?AP-1?and NF-κB?expression. Biomed Pharmacother.?2019 Jun 6;117:109074. WB ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 細(xì)胞凋亡 細(xì)胞膜受體 自然殺傷細(xì)胞 t-淋巴細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 25kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD137: 101-200/255 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
CD137 exists on the cell surface as a monomer with a molecular mass of 30 kDa and as a dimer of 55 kDa. Human and mouse CD137 share 60% amino acid identity. CD137 (4-1BB), a member of the tumour necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. Function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. Subunit: Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed on the surface of activated T-cells. Similarity: Contains 4 TNFR-Cys repeats. SWISS: Q07011 Gene ID: 3604 Database links: Entrez Gene: 3604 Human Omim: 602250 Human SwissProt: Q07011 Human Unigene: 654459 Human CD137屬于腫瘤壞死因子超家族成員，是可誘導(dǎo)的T細(xì)胞共刺激受體，表達(dá)于CD4 + 和CD8 + T細(xì)胞、活化的自然殺傷細(xì)胞（natural killercell，NK）和樹突狀細(xì)胞,CD137可抑制T細(xì)胞增殖，誘發(fā)細(xì)胞凋亡。 |
| 產(chǎn)品圖片 |
Sample:
HepG2(Human) Cell Lysate at 30 ug
Primary: Anti-CD137 (bs-2449R) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 25 kD
Observed band size: 39 kD
Sample:
Lane 1: Mouse Thymus Lysates
Lane 2: Mouse Spleen Lysates
Lane 2: Mouse Lymph Lysates
Primary: Anti-CD137 (bs-2449R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 25kDa
Observed band size: 42kDa
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